Workshop 2017

Recap of the 2017 NMR Validation Workshop

On February 24, 2017, approximately 50 people convened at the Validation Workshop to discuss the NMR Validation Wiki platform, recapped other events in the NMR community over the prior year, and learned from various flash presentations.

 

The Validation Workshop takes place following the PANIC Conference each year.  This year, we were very excited to have a turnout of over 50 people, which represents an increase from the previous year. We began the day with an introduction from both Kim Colson (Bruker Biospin) and Torsten Schönberger (Bundeskriminalamt). The group reaffirmed the goals of the forum, including:

  • Identify a network of NMR people concerned with validation that can ultimately assist each other through the validation process;
  • Harmonize the terminology and a standard approach for NMR validations;
  • Position the guidelines produced by consensus of the NMR community so that accreditation agencies can use this process.

 

 

An summary of last years’ Workshop, that identified issues in the validation community with solutions and actions, gave the attendees a quick start to the day. Attendees also benefited from learning the highlights of other meetings including the validation workshop at SMASH (June 2016) and the qNMR meeting held at Spectral Service in Cologne, Germany (October 2016).  To further enhance progress of this community, our Validation Fellow, Kaylen Obray, (Colorado State University), presented the group’s new website, ValidNMR, and newsletter, which aim to keep the community informed throughout the year. Kaylen was the first recipient of the Bruker Fellowship for Excellence in NMR Validation, presented by PANIC annually.

 

Informative presentations on qNMR were given by Bernd Diehl (Spectral Service) and Sitaram Bhavaraju (US Pharmacopeial Convention) and on multivariate NMR methods by Yulia Monakhova (Spectral Service). One of the most exciting and dynamic parts of our workshop was the collection of flash presentations ranging from qNMR, chemometrics, calibration standards and interlaboratory comparisons, presented by Markus Obkircher (Millipore Sigma), Toru Miura (Wako), Vito Gallo (Innovative Solutions), Elina Zailer (Spectral Service). Please feel free to view and/or download the presentations from the 2017 NMR Validation Workshop! Presentations can be downloaded in the Member’s Area.

 

The most accomplishing feat of the Validation Workshop was introduced by Claudia Boot (Colorado State University) and Torsten Schönberger (Bundeskriminalamt) with the start of development of NMR Validation Wiki pages that aim to serve this community with up-to-date information on current practices in NMR Validation. We broke into teams to address  the most important categories that include: Quantitative NMR, Qualitative NMR, Protocols, Nomenclature, Education, Interlaboratory Comparisons, Chemometrics, and Reference Material and Data. Each category now has a chairperson and a team for moving forward in constructing the NMR Validation Wiki!

More information for the Wiki can be viewed here.

 

2017 NMR Validation Workshop Agenda

8:00 am Coffee (hand out survey)

 

8:30 am Welcome, Progress, Introducing Kaylen Obray, Today’s Goals Kim Colson (Bruker BioSpin)

 

8:50 am Summary of 2016 WW Meetings Torsten Schönberger (Bundeskriminalamt)

 

9:10 am  “Breakthrough in qNMR literature: announcement of a new handbook” Bernd Diehl (Spectral Service)

 

9:35 am “qNMR in Pharmacopeial Analysis” Sitaram Bhavaraju (U.S. Pharmacopeial Convention)

 

10:00 am Discussion

 

10:15 am Break

 

10:45 am NMR Validation Website & Scholar Initiatives Kaylen Obray (Colorado State University)

 

11:00 am Discussion: Website, Editorial Board Portals, Wiki, News, Validation Education

Moderators: Claudia Boot (CSU) and Torsten Schönberger (Bundeskriminalamt)

  • Define Portals and Moderators: qNMR, chemometrics, reference standards, round robin studies, nomenclature…
  • Wiki Introduction (Kristie Adams, DuPont)
  • Flash Presentations
    • “Interlaboratory comparisons for NMR methods validation and for setup of new metrics in performance assessment” Vito Gallo (Politecnico di Bari)
    • Round Robin Tests Elina Zailer (Spectral Service AG)
    • Reference Materials Markus Obkircher (Millipore Sigma)

 

12:15 pm Lunch (hand in survey)

 

1:00 pm “Validation of multivariate NMR methods: case studies of heparin and lecithin” Yulia Monakhova (Spectral Service)

 

1:25 pm Discussion

 

1:40 pm Wiki Portals Workshop

  • 40 min Round 1: Split into Portals
  • 40 min Round 2: Split into Portals
  • 15 min: Kaylen: Volunteers for newsletter articles
  • Moderators: tbd

 

3:15 pm Break

 

3:30 pm “Mind the Gap: Assessing the Impact of Outsourcing on NMR Method Validation Protocols” Kristie Adams (DuPont)

 

4:00 pm Wrap-Up Discussion: “What we’ve learned, setting our path forward and plans for next year” Kim Colson (Bruker BioSpin) and Torsten Schönberger (Bundeskriminalamt)

 

4:45 pm Close of 2017 Validation Workshop